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Most ingredients in Gabatrol have a GRAS (Generally Recognized As Safe) rating as determined by the Food and Drug Administration.. |
As a dietary supplement, follow the following dosage guidelines or an an as needed basis:
Mild Effects: 3-4 capsules
Moderate Effects: 5-6 capsules
Strong/Enhanced Effects: 7+ capsules
Persons over 200 lb may want to start with the Moderate Effects dosage. Works best on an empty stomach.
Gabatrol may increase sensitivity to alcohol, therefore, do not use if consuming alcohol. Read Warning Label.
Caution: If you are pregnant, nursing or currently taking any medication, consult with a physician prior to use. Do not exceed suggested use.
Storage: Store this product in a cool dry place below 30C (86F). Keep out of reach of children.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, cure or prevent any disease(s).
4A3P is an amino acid with potent neuropsychotropic effects. Derived from the neurotransmitter Gamma Amino Butyric Acid (GABA) that is capable of passing the blood bran barrier. 4A3P is also called a nootropic or "smart drug" for its ability to improve neurological functions. It was discovered in Russia in the 1960's, and has since been used there to treat a wide range of ailments including anxiety and insomnia. It is safe and well tolerated having been extensively researched since the 1960’s in a variety of studies. Only Gabatrol has this new form of GABA!
References:http://en.wikipedia.org/wiki/Phenibut | Farmakol Toksikol 1988 Jul-Aug;51(4):20-2;1990 Sep-Oct;53(5):45-7 | Eksp Klin Farmakol. 2002 Jan-Feb;65(1):77-80; 2003 Jul-Aug;66(4):21-4; 2005 May-Jun;68(3):42-5;2006 Jul-Aug;69(4):23-7 Vestn Ross Akad Med Nauk. 2005;(2):35-40.| CNS Drug Rev. 2001 Winter;7(4):471-81
Gamma-glutamylethylamide is an amino acid commonly found in tea. In 1950 the Tea laboratory of Kyoto successfully separated Theanine from Gyokuro leaf, which has the most Theanine content among all teas. Theanine is related to glutamine, and can cross the blood-brain barrier.Because it can enter the brain, Gamma-glutamylethylamide has psychoactive properties. Gamma-glutamylethylamide has been shown to reduce mental and physical stress, may produce feelings of relaxation and improves cognition and mood when taken in combination with caffeine.Gamma-glutamylethylamide is speculated to produce these effects by increasing the level of gamma-aminobutyric acid (GABA) production. Theanine increases brain serotonin, increases dopamine, GABA levels and has micromolar affinities for AMPA, Kainate and NMDA receptors. Gamma-glutamylethylamide also promotes alpha wave production in the brain.
References:http://en.wikipedia.org/wiki/L-theanine | Biol Psychol. 2006 Aug 21 | Nagoya University Department of Psychology, Chikusa-ku, Nagoya, 464-8601, Japan | Psychopharmacology (Berl). 2007 Sep 23 | Rogers PJ, Smith JE, Heatherley SV, Pleydell-Pearce CW. Department of Experimental Psychology, University of Bristol, 12a Woodland Road, Bristol, BS8 1TU, UK | Food Chem Toxicol. 2006 Jul;44(7):1158-66 | Borzelleca JF, Peters D, Hall W. Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA; In Vivo. 2004 Jan-Feb;18(1):55-62 | Neurosci Lett. 2004 Jun 3;363(1):58-61
One of the 20 amino acids that are used by cells to synthesize proteins and is a starting material for neurotransmitters and increases plasma neurotransmitter levels (particularly dopamine and norepinephrine) but has little if any effect on mood.The effect on mood is more noticeable in humans subjected to stressful conditions. A number of studies have found tyrosine to be useful during conditions of stress, cold, fatigue, prolonged work and sleep deprivation, with reductions in stress hormone levels, reductions in stress-induced weight loss seen in animal trials, improvements in cognitive and physical performance seen in human trials.
References:http://en.wikipedia.org/wiki/L-tyrosine | J Psychopharmacol. 2005 Jan;19(1):5-11
2AAA is a conditionally essential amino acid found abundantly in the body, particularly throughout the excitable tissues of the central nervous system, where it is thought to have a regulating influence. However, 2AAA is deficient in many diets and may not be sufficiently produced by the body in certain disease states. Its many functions in the body include:
1. Anti-oxidant: 2AAA is a cell membrane stabilizer and is known to protect against retinol toxicity and lipid peroxidation.
2. Immunostimulant: 2AAA increases lymphocyte viability in a dose-dependant manner. 2AAA also activates natural-killer cells and stimulates the release of interleukin
(IL-I) from macrophages.
3. Detoxifying agent: 2AAA reacts with the carboxylic acid group of toxins to form amide linkages which are excreted through the kidneys.
4. Neurologic disorders: through neuronal cell membrane stabilization 2AAA reduced seizures in an animal model of human epilepsy. Brain tissue samples show that over two-thirds of migraine/epileptic patients had reduced 2AAA levels.
5. Cardiovascular: 2AAA is the most abundant and important amino-acid in the heart. It stimulates cAMP activity, and is used in Japan to treat congestive heart failure (2-4 g daily), arrhythmias, duiresis and hypertension. It also lowers the cardiovascular effects of oxidative stress associated with iron-overload.
References:http://en.wikipedia.org/wiki/Glycine
2ASA is a small amino acid with many positive health effects. Recent reviews in the scientific literature have had titles like “[2ASA]– an inert amino acid comes alive” and “[2ASA]: a novel antiinflammatory, immunomodulatory, and cytoprotective agent.” As research into this conditionally-essential amino acid has progressed, the health impacts associated with the real limits of availability of 2ASA– and the benefits of supplementation well above the levels readily available from the diet – have become increasingly clear. 2ASA is emerging as a critical unsung hero of human nutrition for brain and body.
References:http://en.wikipedia.org/wiki/Taurine | Neurochem Res. 2007 Aug 31 | Department of Public Health, School of Preclinical Medicine, Chengdu Medical College, 601 Rongdu Road, Jinniu District, Chengdu, 610081, China
Sceletium tortuosum is a succulent herb commonly found in South Africa, which is also known as Kanna, Channa, Kougoed (Kauwgoed) - which literally means, 'chew(able) things/goodies' or 'something to chew'. The plant has been used by South African pastoralists and hunter-gatherers as a mood-altering substance from prehistoric times.
Sceletium is known to elevate mood and decrease anxiety, stress and tension. It has also been used as an appetite suppressant by shepherds walking long distances in arid areas. In intoxicating doses it can cause euphoria, initially with stimulation and later with sedation. Users also report increased personal insight, interpersonal ease and a meditative, grounded feeling without any perceptual dulling. Others have noted enhanced tactile and sexual response. High doses produce distinct inebriation and stimulation often followed by sedation. The plant is not hallucinogenic, contrary to some literature on the subject, and no adverse effects have been documented.
References:http://en.wikipedia.org/wiki/Sceletium_tortuosum
Bioperine's value is that it has been established to enhance the bioavailibility of certain supplements through increased absorption. In other words, when combined with Bioperine, numerous vitamins, minerals, amino acids and anti oxidants are more effeciently absorbed and utilized in the body.
References:http://www.bioperine.com/clinical_studies.htm
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